Search results for "Body water"

Adaptive physiological water conservation explains hypertension and muscle catabolism in experimental chronic renal failure

2021

Abstract Aim We have reported earlier that a high salt intake triggered an aestivation‐like natriuretic‐ureotelic body water conservation response that lowered muscle mass and increased blood pressure. Here, we tested the hypothesis that a similar adaptive water conservation response occurs in experimental chronic renal failure. Methods In four subsequent experiments in Sprague Dawley rats, we used surgical 5/6 renal mass reduction (5/6 Nx) to induce chronic renal failure. We studied solute and water excretion in 24‐hour metabolic cage experiments, chronic blood pressure by radiotelemetry, chronic metabolic adjustment in liver and skeletal muscle by metabolomics and selected enzyme activity…

Training-induced protection and effect of terminated training on exercise-induced damage and water content in mouse skeletal muscles.

1995

Muscle swelling in connection with training-induced protection against exercise-induced damage and the disappearance of the protective adaptation after termination of training was studied in male NMRI-mice, aged 8 weeks at the beginning of the experiment. Mice were randomly assigned to several different treatment groups (training, training-exercise, exercise, detraining, detraining-exercise, together with their respective controls). Training and prolonged exercise sessions were performed by running uphill (6 degrees) on a motor-driven treadmill. Muscle damage was estimated by the total activity of beta-glucuronidase and water content from the red parts of m. quadriceps femoris (MQF), m. sol…

Short-term walking physical training and changes in body hydration status, B-type natriuretic peptide and C-reactive protein levels in compensated co…

2008

BACKGROUND: Congestive heart failure (CHF) is associated with decreased exercise tolerance, alterations in body fluid balance and activation of neurohumoral and inflammatory pathways. Physical training, despite the contraindications of the past, is recommended for its beneficial effects on exercise capacity and quality of life. We investigate the effects of a short-term (ten weeks) walking physical training program (PT) on body hydration state (HS), B-type natriuretic peptide (BNP) and C-reactive protein (CRP) levels. METHODS AND RESULTS: 22 patients with CHF (mean age 62.7+/-4.8 years, 15 men, mean ejection fraction 38.9+/-3.6%, NYHA class II-III), were enrolled. Eleven patients were rando…

Running-induced muscle injury and myocellular enzyme release in rats

1994

The relationships and time course of exercise-induced muscle damage, estimated by beta-glucuronidase activity and microscopy, to muscle swelling, estimated by muscle water content and microscopy, and to the serum activity of creatine kinase (CK) and the concentration of carbonic anhydrase III were studied in rats 2, 12, 48, and 96 h after 90 min of intermittent running uphill (+13.5 degrees) or downhill (-13.5 degrees) at a speed of 17 m/min. The injury was more pronounced in soleus after uphill running and in the red parts of quadriceps femoris and in the white part of vastus lateralis after downhill running, whereas triceps brachii was not damaged. Increase in muscle water content preced…

Mass movements (landslides) and environmental features in an area Of Alto Belice Destro (High Right Belice) Western Sicily - Italy

2007

Aestivation Motifs Explain Hypertension and Muscle Catabolism in Experimental Chronic Renal Failure

2020

Chronic renal failure leads to muscle mass loss and hypertension, which according to textbook teaching occur secondary to an inability of the kidneys to excrete solutes and water. We found instead that rats with experimental chronic renal failure constantly lost body water, because their kidneys could not sufficiently concentrate the urine. Physiological adaptation to body water loss, termed aestivation, is an evolutionary conserved survival strategy that relies on complex physiologic-metabolic adjustment across multiple organs to prevent otherwise lethal dehydration. We show that rats with chronic renal failure utilize these ancient water conservation motifs to successfully stabilize their…

''Sex Differences In Ultra-triathlon Performance At Increasing Race Distance''

2013

Ruest, Christoph Alexander | Knechtle, Beat | Knechtle, Patrizia | Rosemann, Thomas | Lepers, Romuald; International audience; ''It has been argued that women should be able to outrun men in ultra-endurance distances. The present study investigated the sex difference in overall race times and split times between elite female and male Ironman triathletes competing in Ironman Hawaii (3.8 km swimming, 180 km cycling, and 42.195 km running) and Double Iron ultra-triathletes (7.6 km swimming, 360 km cycling, and 84.4 km running). Data from 20,638 athletes, including 5,163 women and 15,475 men competing in Ironman Hawaii and from 143 women and 1,252 men competing in Double Iron ultra-triathlon ra…

Contribution of genetic and environmental factors to variation in body compartments--a twin study in adults.

2004

This study aimed at analyzing the contribution of genetic and environmental factors on phenotypic variation of various traits of body composition. Subjects were 30 same-sexed pairs of twins including 20 monozygous (MZ) and 10 dizygous (DZ) pairs, aged 19-62 years. Zygosity was determined by DNA typing and morphological diagnosis. Body composition parameters (fat mass FM, lean body mass LBM, body cell mass BCM, extracellular mass ECM, total body water TBW, extracellular water ECW, and intracellular water ICW) were estimated by tetrapolar bioelectrical impedance analysis. Potential environmental factors influencing body composition (number of children, sporting activity and smoking behaviour)…

Intestinal absorption pathway of gamma-aminobutyric acid in rat small intestine.

1994

Intestinal absorption of gamma-aminobutyric acid (GABA), as a model compound for gamma-aminoacids, has not been extensively studied from the kinetic viewpoint. Since data from our laboratory suggested that some competition arises between intestinal absorption of beta-alanine and GABA and since our intent was to maintain the aqueous stagnant diffusion layer in order to approach absorption tests to in vivo physiological conditions, a rat jejunum in situ study was undertaken in order to gain an insight into the mechanism of GABA absorption. In the present paper, results from assays using isotonic perfusion solutions with starting GABA concentrations ranging from 1 to 50 mM are reported. They s…

Beneficial Intervertebral Disc and Muscle Adaptations in High-Volume Road Cyclists.

2018

Purpose Cycling is widely practiced as a mode of transportation, a leisurely pursuit, and a competitive sport. Approximately half of cyclists experience low back pain. Yet, there has been limited study of spine tissue adaptations due to cycling.Methods To investigate potential risk factors for spinal pain, we compared 18 high-volume cyclists (>150 kmwk(-1) for 5 yr) to 18 height-matched nonsporting referents. Participants had no history of spinal pathology. Magnetic resonance imaging was used to quantify intervertebral disc (IVD) morphology and hydration, and psoas, erector spinae, quadratus lumborum, and multifidus muscle size and fat content. Endurance of trunk muscles (flexors and extens…